氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停疗效观察

目的观察氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停的疗效。方法选择自2003年1月至2008年3月在笔者所在医院新生儿病房住院的诊断为原发性呼吸暂停早产儿70例，随机分为治疗组和对照各35例。两组病例在首次发生呼吸暂停之后，均给予氨茶碱负荷量5mg／kg，于20min内静滴注，12h后给2mg／kg的维持量，每隔12h静脉滴注一次。治疗组同时加用纳洛酮，首次0．1mg／kg静脉注射，继而按0．1mg／kg加入10％葡萄糖注射液20ml以0．02—0．04mg／（kg·h）静脉泵入。结果治疗组显效率71．4％，总有效率96．1％，对照组显效率41．7％，总有效率71．4％，显效率比较，=3．92，P〈0．05，总有效率比较X^2=6．67，P〈0．01，差异均有统计学意义。结论氨茶碱联合纳洛酮治疗早产儿原发性呼吸暂停比单用氨茶碱有显著的疗效，并对减少早产儿的后遗症有重要的意义。

Clinical therapeutic offect of aminophyuine associated with naloxone on primary apnea of premature infant

Objective To reseorch the clinical therpeutic effect of aminophylline assciatcd with naloxone, on Primary apnea of premature infant. Methods From January 2003 to March 2008,70 premature infants sufferiny from primary apnea in our hospital were divided into two groups. One was treatment group（35 caces） ,the other was control group （35 cases） ,All the members of the two groups were given intravenously 5 mg/kg of first dose of amin ophyuine and the 2 mg/kg maintenance dose of aminophyluine 12 hours later The members in the treatment group were given naloxone in addition to aminophylline, The first dose of naloxone was 0.1 mg/kg and then naloxone was droppde into patients at 0. 02 - 0. 04mg/（kg·h）. Results In the treat -ment group the effectual rate 71.4% and total effective rate were96. 1%. At the same time,the effectual rate 45.7% and total effective rate 71.4%. The effectual ratio of treatment group was higher than that of con - trol group and so was the total effective rate, there is a significant difference between the control group and the treatment group in effectual ratio （X^2 = 3.92 ,P 〈 0. 05 ）and a highly significant difference between the two groups in total effective ratio （X^2 = 6. 67, P 〈 0. 01 ）. Conclusions Clinical therapeutic effect on primary apnea of premature infants with aminophyline and naloxone is more effective than with aminophylline alone.