MR-DWI评价兔VX2肾移植瘤TACE疗效的实验研究

目的 探讨MR-DWI评价兔VX2肾移植瘤TACE疗效的应用价值.方法 新西兰大白兔22只,采用瘤块埋植法建立兔VX2肾移植瘤模型,经导管动脉化疗栓塞术治疗兔VX2肾移植瘤,MR检查评价兔VX2肾移植瘤TACE术疗效.结果 经导管动脉化疗栓塞术治疗后实验组肿瘤坏死明显,术后第3天瘤区ADC值（1.321±0.125）×10^-3mm^2/s明显增高于术前ADC值（1.139±0.072）×10^-3 mm^2/s（P＜0.05）；对照组术前术后ADC值差别无统计学意义（P＞0.05）.结论 经导管动脉化疗栓塞术是一种创伤小、疗效确切的兔VX2肾移植瘤治疗方法,MR-DWI是一种评价TACE术疗效的有效影像学方法.

MR-DWI Therapeutic Evaluation after Chemoembolization of VX2 Carcinoma Implanted in Rabbit Kidney

Objective To explore the value of MR-DWI in ewduating the effect of TACE for rabbils renal VX2 tumor. Methods Twenty two New Zealand white rabbits with VX2 tumor tissue inoculated directly into the exposed kidney by tumor blocks embedding. The rab- bit renal VX. tum~rs were treated with TACE. The effect of TACE for rabbit＇s renal VX, tumor were observed by DWI. Results The tumor was necrosis obviously ＇after TACE. The ADC value was increased three days after ＇FACE （ P 〈 0.05 ）. No diffe,＇ence was found between the ADC values before and after the administration of normal saline（ P 〉 0.05 ）. Conclusion TACE is a miuor trauma and effective treatment for rabbits VX, renal tumor,MR-DWI is a convenient and effective imaging method to evaluate the effect after TACE.