| 九节龙皂苷衍生物的合成及其抗肿瘤活性 |
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| 引用本文： | 王丽,王荣,校鑫,匡永清,王晓娟.九节龙皂苷衍生物的合成及其抗肿瘤活性[J].中国药师,2013,16(1):6-8. |
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| 作者姓名： | 王丽 王荣 校鑫 匡永清 王晓娟 |
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| 作者单位： | 湖南大学化学化工学院;第四军医大学口腔医院 |
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| 基金项目： | 国家自然科学基金项目(编号:30973623);陕西省资源主导型产业关键技术(链)项目(编号:2011KTCL03-01);第四军医大学优秀文职人员培养基金(编号:00003383) |
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| 摘 要： | 目的:合成九节龙皂苷衍生物并研究其抗肿瘤活性。方法:以九节龙皂苷Ⅰ为先导物,对其30位醛基进行结构修饰,合成一系列衍生物,通过体外细胞培养方法检测其对9种常见肿瘤细胞系的抗肿瘤活性。结果:获得了3个新的皂苷修饰物,其中化合物1和化合物3对常见的9种瘤株的IC50与原皂苷相比均降低（P<0.05）,化合物1和化合物3对肿瘤细胞的抑制率较原皂苷增强。结论:通过对九节龙皂苷进行结构修饰,能增加其抗肿瘤活性。
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| 关 键 词： | 九节龙皂苷 结构修饰 抗肿瘤活性 |
| 收稿时间： | 2012/8/29 0:00:00 |
| 修稿时间： | 2012/10/17 0:00:00 |
Synthesis and Anti-tumor Activities of Ardipusilloside Derivatives |
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| Wang Li,Wang Rong,Xiao Xin,Kuang Yongqing and Wang Xiaojuan.Synthesis and Anti-tumor Activities of Ardipusilloside Derivatives[J].China Pharmacist,2013,16(1):6-8. |
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| Authors: | Wang Li Wang Rong Xiao Xin Kuang Yongqing and Wang Xiaojuan |
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| Institution: | 1.College of Chemistry and Chemical Engineering,Hunan University, Changsha 410082,China;2.Department of Pharmacology,College of Stomatology,the Fourth Military Medical University) |
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| Abstract: | ABSTRACT Objective: To synthesize ardipusilloside (ADS) derivatives and evaluate their anti-tumor activities. Method:A series of chemical compounds were synthesized by the modification of 30-aldehyde group in ardipusilloside, and the anti-tumor activities of the three compounds were studied. Result:Three new compounds were synthesized, and two of which could enhance the anti-tumor activity when compared with ADS. Conclusion:The study establishes a synthetic method for ardipusilloside derivatives and the anti-tumor activities are worthy of further study. |
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