安心颗粒抗心律失常及心肌缺血的作用研究

目的研究安心颗粒对心律失常和心肌缺血的改善作用。方法制备氯化钙、氯仿和乌头碱所致的小鼠心律失常模型及异丙肾上腺素（ISO）引起的小鼠心肌缺血模型,经安心颗粒治疗后,通过观察室颤发生率和心动过速的发生时间等指标评价其抗心律失常作用;通过检测血清超氧化物歧化酶（SOD）、脂质过氧化产物丙二醛（MDA）、乳酸脱氢酶（LDH）和磷酸肌酸激酶（CK）等指标评价其改善心肌缺血的作用。结果安心颗粒可降低氯仿诱发小鼠的室颤发生率;延迟氯化钙引起大鼠室性心动过速的发生时间;提高大鼠对乌头碱的耐受剂量。在ISO所致心肌缺血模型中,安心颗粒可增加SOD的活性,减少MDA的含量,降低血清LDH、CK的水平。结论安心对氯仿、氯化钙和乌头碱引起的心率失常及ISO引起的心肌缺血均有较好的改善作用。

Study on the improvement effects of Anxin on arrhythmias and myocardial ischemia

Objective To investigate the improvement effects of Anxin on experimental arrhythmias and myocardial ischemia.Methods Three kinds of arrhythmic animal model which inhalation of chloroform to mice,administration of CaCl2 and aconitine to rat were used,the changes of arrhythmias were observed by lead Ⅱ dynamic ECG.In myocardial ischemia animal model which injection of ISO,the contents of MDA,SOD,CK and LDH in serum were assayed,respectively.Results Anxin could delay the onset time of arrhythmias and shorten the recovering time to normal heart rate and cardiac arrest（CA） caused by CaCl2in rats;Markedly increased the threshold dose of CA caused by aconitine in rats.Anxin showed not only the concentration of MDA,CK,LDH were decreased,but also SOD activity in serum were increased in mice compared with ISO injection only.Conclusion Anxin has significantly anti-arrhythmic and improve myocardial ischemia effects.