High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic |
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Authors: | Hübschen J M Jutavijittum P Thammavong T Samountry B Yousukh A Toriyama K Sausy A Muller C P |
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Institution: | Institute of Immunology, Centre de Recherche Public-Santé/Laboratoire National de Santé, Luxembourg, Luxembourg. |
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Abstract: | Sera from 105 anti-HCV-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in Laos were investigated by PCR. Forty-five samples were positive for HCV (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. Three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. Two samples were mixed infected with different subtypes or clusters of genotype 6 viruses. |
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Keywords: | Genotype HCV Laos phylogeny subtype |
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