生存蛋白和血管内皮生长因子在子宫内膜异位症组织中的表达

目的探讨生存蛋白在子宫内膜异位症组织中的表达及其与血管内皮生长因子（VEGF）的关系。方法采用免疫组织化学法检测生存蛋白和VEGF在51例异位子宫内膜组织及22例正常子宫内膜组织中的表达。结果生存蛋白在异位子宫内膜组织和正常子宫内膜组织中的表达率分别为52.94%、9.09%,差异有统计学意义（χ^2=12.34,P〈0.01）。VEGF在异位子宫内膜组织和正常子宫内膜组织中的表达率分别为68.63%、18.18%,差异有统计学意义（χ^2=14.48,P〈0.01）;生存蛋白和VEGF在异位子宫内膜组织中的表达呈正相关（r=0.8755）。结论生存蛋白和VEGF在子宫内膜异位症组织中异常表达对子宫内膜异位症的发生起着重要作用。

Expression of gene survivin and its correlation with VEGF in endometriosis

Objective To investigate the role of survivin in endometriosis and its correlation with vascular endothlial growth factor (VEGF) in angiogenesis.Methods Immunohistochemical streptavidin biotin peroxidase was applied to examine the expression of survivin and VEGF,in 22 normal,and 51 ectopic endometrial tissues.Results Survivin was detected in 27 of 51(52.94%) ectopic endometrial tissues,but 9.09% in normal endometria;the expression of survivin in the two groups was significantly different(χ2=12.34,P<0.01);VEGF was detected in 34 of 51(68.63%) ectopic endometrial tissues,but 18.18% in normal endometria;the expression of VEGF in the two groups was significantly different(χ2=14.48,P<0.01);survivin and VEGF had the positive relation in the ectopic endometriumal expression of adenomyosis patient(r=0.8755).Conclusions Survivin and VEGF plays an important role in the development of endmetriosis.