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| 尿激酶型纤溶酶原激活剂及其受体在髓母细胞瘤中的表达研究 | |
| 引用本文： | 王勇,毛伯镛,高利民,王洪新,丁新民,程宏伟,高山.尿激酶型纤溶酶原激活剂及其受体在髓母细胞瘤中的表达研究[J].中华神经外科疾病研究杂志,2002,1(4):340-343. |
| 作者姓名： | 王勇 毛伯镛 高利民 王洪新 丁新民 程宏伟 高山 |
| 作者单位： | 1. 四川大学华西医院神经外科 2. 成都363医院神经外科,四川,成都,610041 3. 新乡市中心医院检验科,河南,新乡,453000 |
| 摘 要： | 目的 研究尿激酶型纤溶酶原激活剂（uPA)及受体（uPAR)在髓母细胞瘤中的表达及临床意义。方法 应用免疫组化LSAB法检测50例髓母细胞瘤中uPA及uPAR的表达，结合临床随访，使用Cox回归统计分析。结果 uPA及uPAR染色定位于肿瘤细胞和血管内皮细胞，Cox回归分析显示uPA及uPAR是影响生存时间的预后因子，它们与预后存在一定的负相关关系。结论 uPA及uPAR可作为预测髓母细胞瘤患预后的客观指标。 |
| 关 键 词： | 髓母细胞瘤 尿激酶 免疫组化 |
| 文章编号： | 1671-2897(2002)01-340-04 |
| 修稿时间： | 2002年4月30日 |
Expression of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in medulloblastomas |
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| WANG Yong,MAO Boyong,GAO Limin,WANG Hongxin,DING Xinmin,CHENG Hongwei,GAO Shan.Expression of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in medulloblastomas[J].Chinese Journal of Neurosurgical Disease Research,2002,1(4):340-343. | |
| Authors: | WANG Yong MAO Boyong GAO Limin WANG Hongxin DING Xinmin CHENG Hongwei GAO Shan |
| Institution: | WANG Yong1,MAO Boyong1,GAO Limin2,WANG Hongxin,DING Xinmin1,CHENG Hongwei1,GAO Shan1 1 Department of Neurosurgery,West China Hospital of Sichuan University,2 Department of Neurosurgery,363 Hospital of Chengdu,Chengdu 610041, 3 Department of Laboratory,Center Hospital of Xinxiang,Xinxiang 453000,China |
| Abstract: | Objective To study expression and clinical significance of urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) in medulloblastomas. Methods Expressions of uPA and uPAR were examined in 50 patients with medulloblastomas using LSAB immunohistochemical technique, and follow-up survey was conducted with Cox regression analysis. Results The staining outcome demonstrated that uPA and uPAR were localized on tumor cells and endothelial cells. Cox regression analysis showed that uPA and uPAR were prognostic factors affecting survival and they had negative correlation with the prognosis. Conclusion The data suggest that uPA and uPAR play a role in predicting prognosis of medulloblastomas. |
| Keywords: | Medulloblastoma Urokinase Receptor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |