不同程度睡眠呼吸暂停综合征患者心率变异性的研究

目的:研究不同程度睡眠呼吸暂停综合征(SAS)患者心率变异性(HRV)的改变,低通气指数(AHI)与心率变异性的相关性。方法:30例通过多导睡眠图监测明确为SAS的患者作为A组,其中AHI小于20的轻度SAS患者16例作为B组,AHI大于20的中重度SAS患者14例作为C组,与对照组20例,进行动态心电图监测,采用HRV的时域分析法分析SAS患者的自主神经活性。结果:(1)A组的HRV指标中除ASDNN与对照组无明显差异,SDNN、SDANN、RMSSD均较对照组明显下降,P<0.01。(2)B组的HRV指标中除ASDNN与对照组无明显差异,SDNN、SDANN、RMSSD均较对照组下降,P<0.05。(3)C组的HRV指标中除ASDNN与对照组无明显差异,SDNN、SDANN均较对照组明显下降,P<0.01,RMSSD较对照组下降,P<0.05。(4)B组与C组之间的HRV指标无差异,P>0.05。结论:SAS患者的HRV下降,但不能以SAS患者的AHI指数来判断HRV下降的严重程度。

Study of the heart rate variability in patients with different extents of sleep apnea syndrome

Objective:To study the change of heart rate variability(HRV) in patients with different extents of sleep apnea syndrome(SAS) and analyse the relationship of AHI and HRV.Methods:30 patients with SAS served as group A,in which 16 patients,whose AHI was lower than 20 served as group B,while 14 patients whose AHI greater than 20 as group C,and 20 controls were involved in this HRV study as control group.Results:(1)Among the indices of HRV in group A,except for ASDNN,SDNN,SDANN and RMSSD decreased significantly compared with those in control group(P<0.01);(2)Among the indices of HRV in group B,except for ASDNN,SDNN,SDANN and RMSSD decreased compared with those in control group(P<0.05);(3)Among the indices of HRV in group C,except for ASDNN,SDNN and SDANN decreased significantly compared with those in control group(P<0.01),RMSSD decreased(P<0.05);(4)There was no significant difference in indices of HRV between group B and group C(P>0.05).Conclusion:Even if the level of HRV in SAS patients decreased,but we could not use the AHI index of SAS patients to judge the serious extent of the reduced HRV.