清肝解毒降酶汤治疗慢性乙型病毒性肝炎YMDD变异患者52例临床观察

目的:观察清肝解毒降酶汤对慢性乙型病毒性肝炎YMDD变异患者的治疗作用。方法:将99例慢性乙型病毒性肝炎YMDD变异患者分为治疗组52例,对照组47例。治疗组予清肝解毒降酶汤,每日1剂煎服;对照组予益肝灵片剂,每次1片,每日3次口服。4周后观察两组血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、—谷氨酰转移酶(GGT)的变化情况。结果:治疗组总有效率88.46%,对照组总有效率68.09%,治疗组疗效优于对照组(P<0.05);肝功能中ALT、AST、GGT值治疗组治疗后均低于对照组(P<0.05或P<0.01)。结论:清肝解毒降酶汤能有效降低慢性乙型病毒性肝炎YMDD变异患者的肝功能指标水平,其疗效明显优于对照组。

Clinical Research on 52 Cases of Chronic Virus B Hepatitis with YMDD Mutation Treated by QingGan JieDu JiangMei Decoction

Objective:To study the curative effects of QingGan JieDu JiangMei Decoction on chronic virus B hepatitis with YMDD mutation.Methods:99cases of chronic virus B hepatitis with YMDD mutation were divided into two groups.The treatment group with52cases was treated with QingGan JieDu JiangMei Decoction1dose/day,while the control group with47cases was given YiGanLing Tablet1pill/time,three times per day.Four weeks later,the observation was made to see the changes of ALT,AST,and GGTin both two groups.Results:The curative effects in the treatment group with the total effective rate as88.46%were better than in the control group with the rate as68.09%(P<0.05).Meanwhile,ALT,AST,and GGTwere lowered more obviously in the treatment group(P<0.05or P<0.01).Conclusions:QingGan JieDu JiangMei Decoction can effectively lower the levels of ALT,AST,and GGT in patients of chronic virus B hepatitis with YMDD mutation.And its curative effects are better than the control group.