Beta-adrenoceptor studies. III. On the beta-adrenoceptors in rat adipose tissue |
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| Authors: | H H Harms J Zaagsma B Van der Wal |
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| Affiliation: | 1. Department of Medicinal chemistry. Section Molecular Pharamcology, Faculty of Science Free University, Amsterdam, The Netherlands |
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| Abstract: | A number of β-adrenoceptor blocking agents were tested for isoprenaline antogonism on rat adipose cells. The pA2 values were compared to pA2 values determined previously on guinea-pig atrial and tracheal preparations. Discrepancies between the results obtained and the hypothesis of Lands et al. (Nature, 214 (1967) 597) concenring the existence of two types of β-receptors are discussed. The classification of the lipolytic β-receptors as a β1-receptor is questioned and another hypothesis is put forward. |
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| Keywords: | Lipolysisl β-Adrenolytics β-Adrenoceptors classification Rat adipose cell |
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