抗血小板和抗凝治疗与梗塞后脑出血的相关性

目的:研究抗血小板、抗凝治疗对梗塞后脑出血(HI)发生率的影响.方法:比较使用阿司匹林、氯噻匹啶、低分子量肝素的脑梗塞(CI)患者HI发生率.结果:所有接受抗血小板、抗凝治疗的CI患者HI发生率均高于无抗血小板、抗凝治疗的患者.HI发生率在阿司匹林(150mg/d)、低分子量肝素(0.6ml/d)、联合使用低分子量肝素(0.6ml/d)和阿司匹林(100mg/d)的CI患者中较高,分别13.33%、12.41%和26.47%.结论:抗血小板、抗凝药物是影响CI患者发生HI的因素之一;不同种类和剂量的抗血小板、抗凝药物对HI发生率影响不同.

Relationship between anti-patelete and anti-coagulation treatment and cerebral hemorrhagic infarction

Objective:To study the influence of anti-patelete and anti-coagulation treatment on incident rate of cerebral hemorrhagia after infarction(HI).Methods:Incident rates of HI in various patients treated with or without aspirin,ticlopidine and nadroparin were compared.Results:Incident rates of HI in patients treated with aspirin,ticlopidine and nadroparin were higher than patients who were not treated with anti-patelete and anti-coagulation.In patients treated with aspirin 150mg per day,nadroparin 0.6ml per day,aspirin 100mg and nadroparin 0.6ml per day,the incident rates of HI were 13.33%,12.41% and 26.47%,respectively.Conclusion:Anti-patelete and anti-coagulation treatment is one of factors influencing on occurrence of HI in patients with cerebral infarction.The influence varies according to different kind of drugs and their dosage.