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Transdermal absorption of nitrendipine from adhesive patches |
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| Authors: | Li-ping Ruan Bing-weng Liang Ji-zhi Tao Chim-hua Yin |
| Affiliation: | a Nanjing No. 454 Hospital, Nanjing, China b Department of Pharmaceulies, China Pharmaceutical University, Nanjing, China |
| Abstract: | The possibility of transdermal administration of nitrendipine was examined on healthy human subjects. Patches containing nitrendipine and Azone ® were prepared, in vitro release and permeation of nitrendipine from patches were investigated, transdermal absorption of nitrendipine from patches was studied in vivo, and clinical trials of nitrendipine patches were conducted in 150 hypertensive patients. Skin irritation was observed neither in rabbits nor in human subjects. |
| Keywords: | Transdermal absorption Nitrendipine Patch Release Permeation Antihypertensive effect |
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