Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160) |
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| Authors: | Kaiser Marcel Wittlin Sergio Nehrbass-Stuedli Angela Dong Yuxiang Wang Xiaofang Hemphill Andrew Matile Hugues Brun Reto Vennerstrom Jonathan L |
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| Affiliation: | Swiss Tropical Institute, Basel, Switzerland. |
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| Abstract: | Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis. |
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