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Lipopolysaccharide-diphosphonate interaction on bone in tissue culture
Authors:E Hausmann  N Weinfeld  S Michaels
Affiliation:1. Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo, New York, U.S.A.;2. Miami Valley Laboratories, The Procter & Gamble Company, Cincinnati, Ohio, U.S.A.;1. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan;2. Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan;3. Forschungszentrum Jülich GmbH, Institute of Energy and Climate Research, 52425 Jülich, Germany;4. Empa, Swiss Federal Laboratories for Materials Science and chnology, Überlandstrasse 129, 8600 Dübendorf, Switzerland;5. Institut für Materialien und Prozesse für elektrochemische Energiespeicher– und wandler, RWTH Aachen University, 52074 Aachen, Germany;6. Center for the Intelligent Semiconductor Nano-system Technology Research, Hsinchu 30078, Taiwan;7. Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu 30013, Taiwan;1. College of Life Science, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu 210095, PR China;2. College of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu 210095, PR China;1. Sapienza University of Rome, Department of Civil, Building and Environmental Engineering, Italy;2. UN-Habitat, Burkina Faso;3. Muncipality of Bobo-Dioulasso, Burkina Faso;1. Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH;2. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH;3. Section of Intestinal Neoplasia and Hereditary Polyposis (INHP), Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH;4. Comprehensive Cancer Center, The Ohio State University, Columbus, OH;1. Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA;2. Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA;3. Department of Neurology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA;4. Clinical and Translational Science Institute (CTSI), Office of Clinical Research (OCR), USA
Abstract:The effect of diphosphonate on bone in culture containing lipopolysaccharides was studied. Lipopolysaccharides stimulated the release of lactate and 45Ca from prelabelled bones into the culture medium. These two stimulatory effects of lipopolysaccharides were blocked by diphosphonate. The results are inconsistent with an action of diphosphonate restricted to reducing bone crystal solubility.
Keywords:
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