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High incidence of other neoplasms in patients with low-grade gastric MALT lymphoma |
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| Authors: | Zucca E; Pinotti G; Roggero E; Comi M A; Pascarella A; Capella C; Pedrinis E; Cavalli E |
| Institution: | 1Servizio Oncologico, Ospedale San Giovanni Bellinzona, Switzerland 2Clinica Medica, Ospedale Multizonale Varese 3Gastroenterologia ed Endoscopia Dtgestiva, Ospedale S'Orsola - FBF Brescia 4Servizo di Anatomia Patologica, Ospedale Multizonale Varese, Italy 5Istituto Cantonale di Palologia Locarno, Switzerland |
| Abstract: | BACKGROUND: Low-grade gastric MALT lymphoma is an uncommon tumour for whicha close association with chronic Helicobacter pylori infectionhas been suggested. However, given the rarity of MALT lymphomaof the stomach despite the high prevalence of H. pylori infection,it seems plausible that genetic host factors might play a fundamentalrole in gastric lymphomagenesis. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 83 patientswith low-grade gastric MALT, all of whom resided in a geographicarea (southern Switzerland and northern Italy) where the incidenceof gastric tumours appears to be uncommonly high. RESULTS: One or more additional cancers were observed in17 of 83 patients(20%, 95% CI 12% to 31%) for a total of 23 tumours. Of these,5 were diagnosed prior to, 12 con-comitantly with, and 7 afterthe gastric MALT lymphoma. Eleven patients had a single additionalsolid tumour (13%, 95% CI 7% to 22%); 3 patients had non-Hodgkin'slymphoma and one had Hodgkin's disease. Multiple additionalcancers were present in 3 cases. Nine of 83 patients have diedand 8 of them of a second cancer. CONCLUSIONS: Unexpectedly an extraordinarily large number of patients withother malignancies was observed in this series. The reasonsfor this finding are still unknown, but genetic alterationsare speculated to play an important role. stomach, MALT lymphoma, non-Hodgkin's lymphoma, solid tumours, second neoplasms |
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