60例脊柱疾病术后舒芬太尼复合氟比洛芬酯镇痛效果分析

目的：探讨舒芬太尼复合氟比洛芬酯用于脊柱手术后镇痛效果。方法：选取我院2011年1月～2012年12月ASAⅠ-Ⅱ级择期骨科脊柱手术患者180例，随机分为A、B、C 3组，每组各60例。3组患者手术结束后即行患者静脉自控镇痛PCIA。 A组术后镇痛用舒芬太尼2g/kg＋生理盐水至100mL。B组舒芬太尼2g/kg＋氟比洛芬酯150mg＋生理盐水至100mL。 C组舒芬太尼4g/kg＋生理盐水至100mL。3组PCIA泵参数设置：背景剂量2ml，单次负荷剂量2ml ，锁定时间15分钟。观察3组患者术后2小时、6小时、12小时、24小时、48小时的静息镇痛评分及PCIA期间恶心、呕吐、头晕、嗜睡、呼吸抑制不良反应发生情况。结果：术后各时间点VAS评分，A组评分高于B组和C组（P＜0．05）， B组和C组镇痛效果良好，B、C 2组VAS评分无统计学意义（P＞0．05））。 PCIA期间不良反应观察中，A、B 2组恶心呕吐，头晕嗜睡的患者均少于C组，并且C组中有2例呼吸抑制，差异有统计学意义（ P＜0．05）。结论：舒芬太尼复合氟比洛芬酯用于脊柱手术后镇痛的效果好，各种不良反应发生率低。

Analgesia effect analysis on 60 cases of spinal disease sufentanil compound flurbiprofen ester postope rative

Objective：To study the compound flurbiprofen sufentanil esters used in effect of analgesia after spinal surgery .Methods：180 cases ASA grade Ⅰ -Ⅱelective orthopaedic spinal surgery patients in our hospital from January 2011 to December 2011 , randomly divided into A, B, C three groups, each group 60 cases.Three groups of patients after surgery in patients with venous self -control anal-gesia PCIA.Postoperative analgesia with sufentanil group A （including 2g/kg ＋saline water to 100 ml.Sufentanil group B （including 2 g flurbiprofen ester 150 mg/kg ＋＋saline to 100 ml.Sufentanil group C （ including 4 g -100 -ml/kg ＋saline water .Three groups of PCIA pump parameters Settings：background dose 2 ml, a single load 2 ml dose, the lock time of 15 min.Observe three groups of pa-tients after 2 h, 6 h, 12 h, 24 h, 48 h resting analgesia scores and during PCIA nausea , vomiting, dizziness, drowsiness, respiratory in-hibition adverse reactions occur .Results：Postoperative VAS score at each time point , group A score higher than that of group B and group C （P〈0.05）, group B and group C analgesic effect is good ,B, C, two groups of VAS score no statistical significance （P 〉0.05））. PCIA adverse reactions during the period of observation , A,B two groups, nausea, vomiting, dizziness, sleepiness in patients were less than group C , and there are two cases of respiratory inhibition in group C , the difference was statistically significant （P 〈0.05）.Con-clusion：Sufentanil compound flurbiprofen esters used in analgesia after spinal surgery effect might be good , all kinds of bad reaction inci-dence was low .