化疗对肿瘤免疫功能影响的研究进展

手术和化疗能有效减少肿瘤负荷，但系统化疗都有致淋巴细胞减少的不良反应，因此传统观念认为化疗会抑制免疫系统，并干扰随后的免疫治疗。最近的一系列研究却有了突破性的发现：系统化疗在导致淋巴细胞暂时减少的同时，机体可通过多个机制改善和提高抗肿瘤免疫应答，且部分化疗药物对机体的免疫治疗起协同作用，化疗联合免疫治疗给肿瘤生物治疗带来新希望与突破点。综述常见化疗药物对肿瘤患者的免疫功能影响。

The Study Progress in the Immune Function of Cancer Patients Treated With Chemotherapy Drugs

Operation and chemotherapy can reduce the tumor burden, however systematical chemotherapy induces lymphocytopenia. So conventional idea consider chemotherapy may inhibit immunologic function, which furthermore interfere with sequential immunotherapy. But some great breakthroughs have been archived by recent research which proves evidence that systematical chemotherapy can improve anti-tumor immune function through multiple mechanisms while companying temporary lymphocytopenia and synergistic antitumor activity of chemotherapy with immunotherapy has been investigated. These findings open a novel field of investigations for future clinical trial design, taking into account the immunostimulatory capacity of chemotherapeutic agents, and using them in combined chemo-immunotherapy strategies.