安多霖降低鼻咽癌和食道癌患者放疗后高微核率的临床研究

探讨安多霖降低鼻咽癌和食道癌患者放疗后高微核率和促进放射损伤修复的作用，将１３８例癌症患者（鼻咽癌６６例，食道癌７２例）随机分为治疗组７６例（鼻咽癌３４例，食道癌４２例），对照组６２例（鼻咽癌３２例、食道癌３０例）放疗结束时口服安多霖胶囊，对照组口服参芪片，每次４粒，３次／ｄ，连用１４ｄ。全组病例均在用药前后各测外周血淋巴细胞微核率（ＭＮＦ）一次。结果显示，ＭＮＦ用药前治疗组与对照组无差异别（Ｐ《

Anduolin Decrease the High Micronucleus Frequencies Following Radiotherapy in Patients with Naso-pharyngeal and Esophageal Carcinoma A Clinical Study

To discuss the role of Anduolin in decreasing the high micro-nucleus frequencies(MNF) caused by radiation and promoting the repairing of radiation damage. 138 cases of malignant carcinoma(66 cases of nasopharyngeal carcinoma and 72 cases of esophageal carcinoma) were randomized into treatment group and control group. There was 76 cases in treatment group including 34 cases of nasopharyngeal carcinoman and 42 cases of esophageal carcinoma, while the control group comprised 62 caese including 32 cases of nasophayngeal carcinoma and 30 cases of esophageal carcinoma. Anduolin capsules were administered orally to the treatment group following radiotherapy, 4 capsules t i d for 14 days,while Senqi tablets were administered to the control group. MNF analysis of the peripheral blood were performed before and after the Anduolin treatment.Results showed thatBefore the Anduoli tratment, the MNF were similar between the two groups(P＞0.1),however, after the Anduolin treatment, the MNF in the treatment group lowered significantly than that of the control group (P＜0.01).The results indicated Anduolin can significantly decrease the high micronucleus frequencies caused by radiation following radiotherapy in patients with malignant carcinoma and promote the repairing of radiation damage, so it may have important clinical value in preventing the radiation damage.