苦参素合拉米夫定治疗对乙型肝炎血清标志物的影响

目的：观察苦参素联合拉米夫定对慢性乙型肝炎血清标志物的影响。方法：慢性乙型肝炎患者109例分为两组,拉米夫定组55例,用拉米夫定治疗;联合组54例,用苦参素联合拉米夫定治疗。比较两组治疗3、6、9个月后HBeAg、HBV-DNA转阴以及9个月后血清HBeAg及HBeAb转换情况。结果：治疗3、6、9个月后两组HBV-DNA转阴率差异均无显著性意义;治疗6、9个月后两组HBeAg转阴率差异有显著性意义。9个月后血清HBeAg及HBeAb转换率差异均有显著性意义。结论：联合用药优于单用拉米夫定。

Effect of Kushensu Combined with Lamivudine on Serum Symbol of HBV

Objective:To obverse the effect of Kushensu combined with Lamivudine on serum symbol of chronicity HBV. Methods:109 cases of chronicity HBV were randomly divided into the Lamivudine group(55 cases)and the combination group(54 cases).The Lamivudine group was treated by Lamivudine and the combination group by Kushensu combined with Lamivudine.The negative ratio of HBeAg and HBV-DNA after treatment for 3.6 and 9 months.and the variation ratio of HBeAg and HBeAb in blood serum after treatment for 9 months were compared.Results:The negative ratio of HBV-DNA after treatment for 3.6 and 9 months had no obviously difference.The negative ratio of HBeAg after treatrnent for 6 and 9 months had obvious difference.The variation ratio of HBeAg and HBeAb in blood seruln after treatment for 9 months had significant difference.Conclusion:Kushensu combined with Lamivudine has better effect on treating chronicity HBV than Lamivudine only.