| 甘草提取物对大鼠体内环孢素药代动力学的影响 |
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| 引用本文： | 朱素燕,胡毅坚,陈江飞,徐萍,龙再浩.甘草提取物对大鼠体内环孢素药代动力学的影响[J].中国临床药理学与治疗学,2011,16(9):971-974. |
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| 作者姓名： | 朱素燕 胡毅坚 陈江飞 徐萍 龙再浩 |
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| 作者单位： | 1. 宁渡市第一医院药剂科,宁波315010,浙江
2. 宁波市出入境检验检疫局,宁波315012,浙江 |
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| 基金项目： | 宁波市医学科技计划项目 |
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| 摘 要： | 目的:研究甘草连续给药7 d对环孢素在大鼠体内的药代动力学影响。方法:12只大鼠随机分为生理盐水对照组和甘草实验组,甘草实验组予甘草提取物(0.5 g/kg,1次/d)连续给药7 d,第8天晨两组均予环孢素灌胃给药后按时间点连续采样,采用荧光偏振免疫分析法测定环孢素的血药浓度,计算并比较主要药动学参数。结果:对照组和实验组的环孢素主要药动学参数Cmax、tmax、t1/2、AUC0-48 h、AUC0-∞、平均滞留时间(MRT)、药物清除率(CL/F)、表观分布面积(V/F)差异均无统计学意义(P>0.05)。结论:甘草连续给药7 d后不影响环孢素在大鼠体内的药代动力学。
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| 关 键 词： | 甘草提取物 环孢素 药代动力学 相互作用 |
Effect of licorice extract on cyclosporine pharmacokinetics in rats |
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| ZHU Su-yan,HU Yi-jiang,CHEN Jiang-fei,XU Ping,LONG Zai-hao.Effect of licorice extract on cyclosporine pharmacokinetics in rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(9):971-974. |
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| Authors: | ZHU Su-yan HU Yi-jiang CHEN Jiang-fei XU Ping LONG Zai-hao |
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| Institution: | ZHU Su-yan1,HU Yi-jiang1,CHEN Jiang-fei1,XU Ping1,LONG Zai-hao21 Department of Pharmacy,Ningbo NO.1 Hospital,Ningbo 315010,Zhejiang,China,2 Ningbo Entry-exit Inspection and Quarantine Bureau,Ningbo 315012 |
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| Abstract: | AIM: To study the effect of licorice extract on cyclosporine pharmacokinetics in rats.METHODS: Experimental rats were randomly divided into the control and test groups which were administrated respectively with normal saline and extract of licorice.After pretreated with extract of licorice(0.5 g/kg,once daily) for 7 days,cyclosporine was given to the rats by intragastric administration in the 8th day.Whole blood cyclosporine concentrations were measured by a fluorescence polarization immunoassay(FPIA).Pharm... |
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| Keywords: | Licorice extract Cyclosporine Pharmacokinetics Interaction |
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