| 锝[99Tc]亚甲基二膦酸盐注射液和阿仑膦酸钠治疗老年骨质疏松症的临床疗效对比观察 |
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| 引用本文： | 潘卫民,王身坚,颜卫文,谢权,周影,王超群.锝[99Tc]亚甲基二膦酸盐注射液和阿仑膦酸钠治疗老年骨质疏松症的临床疗效对比观察[J].中国临床药理学与治疗学,2011,16(9):1030-1033. |
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| 作者姓名： | 潘卫民 王身坚 颜卫文 谢权 周影 王超群 |
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| 作者单位： | 海南医学院附属医院核医学科,海口570102,海南 |
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| 基金项目： | 海南省卫生厅重点科研项目 |
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| 摘 要： | 目的:观察锝99Tc]亚甲基二膦酸盐注射液(云克)和阿仑膦酸钠治疗老年性骨质疏松症患者的临床疗效与安全性。方法:采用随机对照方法,80例骨质疏松患者分为阿仑膦酸钠组(n=40)和云克组(n=40),两组服用足量基础药物钙剂和维生素D同时分别增行阿仑膦酸钠和云克的治疗。疗程结束后,用数字模拟评分法(VAS)及测定骨密度(BMD)评定疗效。结果:阿仑膦酸钠组、云克组两组治疗后腰背痛均有缓解,组间比较云克组止痛起效快,改善最为显著(P<0.05)。阿仑膦酸钠组、云克组两组治疗后BMD均有一定增加,BMD的增加以云克组治疗后6个月最为显著(P<0.05)。结论:对于严重的老年骨质疏松症,云克可在短期内迅速缓解疼痛,增加BMD。阿仑膦酸钠安全性较好,在老年骨质疏松症的长期药物治疗中具有极大的优越性。
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| 关 键 词： | 老年骨质疏松症 锝[99Tc]亚甲基二膦酸盐注射液 阿仑膦酸钠 |
Comparison of clinic efficacy between 99 Tc-MDP and alendronate in patients with senile osteoporosis |
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| PAN Wei-min,WANG Shen-jian,YAN Wei-wen,XIE Quan,ZHOU Ying,WANG Chao-qun.Comparison of clinic efficacy between 99 Tc-MDP and alendronate in patients with senile osteoporosis[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(9):1030-1033. |
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| Authors: | PAN Wei-min WANG Shen-jian YAN Wei-wen XIE Quan ZHOU Ying WANG Chao-qun |
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| Institution: | PAN Wei-min,WANG Shen-jian,YAN Wei-wen,XIE Quan,ZHOU Ying,WANG Chao-qun Department of Nuclear Medicine,Hainan Medical University,Haikou 570102,Hainan,China |
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| Abstract: | AIM: To compare the clinical efficacy and safety of 99 Tc-MDP and alendronate therapy on senile osteoporosis.METHODS: Adult patients(n=80) with senile osteoporosis were randomized into Group alendronate(n=40)and Group 99 Tc-MDP(n=40),all patients were given full dosage of calcium agent and vitamin D therapy.Group alendronate(n=40) were given alendronate;Group 99 Tc-MDP(n=40) were given 99 Tc-MDP.After treatment,the efficacy was evaluated by the digital analog score(VAS)of the pain and detecting bone mineral... |
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| Keywords: | Senile osteoporosis 99 Tc-MDP Alendronate |
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