| 二膦酸盐应用于血液透析患者及其对胰岛素样生长因子的影响 |
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| 引用本文： | 丁晓凯,陈天新,陈波,薛增奇,徐玉兰.二膦酸盐应用于血液透析患者及其对胰岛素样生长因子的影响[J].中国临床药理学与治疗学,2011,16(10):1153-1156. |
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| 作者姓名： | 丁晓凯 陈天新 陈波 薛增奇 徐玉兰 |
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| 作者单位： | 1. 温州医学院附属第一医院肾内科,温州325003浙江
2. 温州医学院附属第三医院肾内科,温州325003,浙江 |
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| 基金项目： | 浙江省医学会临床科研基金资助项目(2008ZYC21) |
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| 摘 要： | 目的:观察维持性血液透析(MHD)骨量异常患者使用二膦酸盐治疗前后骨密度和胰岛素样生长因子等骨代谢生化指标的变化。方法:45例骨量异常(骨量减少或骨质疏松)血液透析患者,在补充钙剂和骨化三醇基础上,应用阿仑膦酸钠70mg/周治疗,分别于治疗前和治疗12个月后检测骨密度及血胰岛素样生长因子-1(IGF-1)、Ⅰ型前胶原氨基端前肽(PINP)、I型胶原C末端肽(CTX),记录不良反应。结果:治疗后血IGF-1水平较治疗前升高(P<0.05),髋部(股骨颈、大转子、全髋)骨密度值较治疗前升高(P均<0.01),血PINP、CTX水平较治疗前明显下降(P均<0.01),但腰椎部位骨密度值改变差异无统计学意义(P>0.05),个别患者出现轻度消化道反应。结论:MHD骨量异常患者应用二膦酸盐治疗,可降低骨转换,有效减少骨量丢失,安全性好。二膦酸盐可能通过提高与骨形成密切相关的血IGF-1水平,提高MHD骨量异常患者的骨量。
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| 关 键 词： | 二膦酸盐 血液透析 骨质疏松 骨密度 胰岛素样生长因子 |
Bisphosphonates used in hemodialysis patients and their effects on insulin-like growth factor |
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| DING Xiao-kai,CHEN Tian-xin,CHEN Bo,XUE Zeng-qi,XV Yv-lan.Bisphosphonates used in hemodialysis patients and their effects on insulin-like growth factor[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(10):1153-1156. |
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| Authors: | DING Xiao-kai CHEN Tian-xin CHEN Bo XUE Zeng-qi XV Yv-lan |
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| Institution: | DING Xiao-kai1,CHEN Tian-xin1,CHEN Bo1,XUE Zeng-qi2,XV Yv-lan1 1 Department of Nephrology,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325003,Zhejiang,China,2 Department of Nephrology,the Third Affiliated Hospital of Wenzhou Medical College |
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| Abstract: | AIM:To observe the change of bone mineral density,insulin-like growth factors and other biochemical markers of bone metabolism before and after treatment with bisphosphonates in maintenance hemodialysis(MHD) patients with osteoporosis. METHODS:45 hemodialysis patients with abnormal bone mass(osteopenia or osteoporosis),in addition to the supplement of calcium and calcitriol,using alendronate 70 mg/weeks,before and after 12 months treatment,the bone mineral density(BMD),serum insulin-like growth factor-1,pro... |
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| Keywords: | Bisphosphonates Hemodialysis Osteoporos Bone mineral density Insulin-like growth factor |
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