溴隐亭治疗垂体泌乳素微腺瘤和大腺瘤的疗效比较

目的:比较溴隐亭治疗脑垂体泌乳素微腺瘤和大腺瘤的临床疗效。方法:脑垂体泌乳素微腺瘤60例;大腺瘤30例。两组均予口服溴隐亭,开始量每晚为1.25 mg,隔3 d增加1.25 mg,直到2.5 mg,Tid;在治疗前及治疗后28周分别测定血清泌乳素,同时做脑垂体磁共振。结果:两组治疗28周后血泌乳素值比治疗前同性别组显著下降(P<0.01),微腺瘤组血泌乳素基本恢复正常,但大腺瘤组无论男女,血泌乳素值仍超过正常值,微腺瘤组与大腺瘤组治疗后同性别相比血泌乳素值有统计学差异(P<0.01)。28周后,垂体泌乳素微腺瘤治愈率为16.7%,总有效率为75.0%,而垂体泌乳素大腺瘤组未发现瘤体消失者,总有效率仅为46.7%。结论:溴隐亭治疗垂体泌乳素微腺瘤可使血泌乳素恢复正常,垂体泌乳素微腺瘤缩小甚至消失;而对泌乳素大腺瘤应采用综合治疗模式,如手术合并药物或结合放射治疗。

Comparison on curative effect of bromocriptine treating pituitary prolactin micro-adenoma and large adenoma

AIM: To compare bromocriptine in the treatment of pituitary prolactin micro-adenoma and the clinical effect of large adenomas. METHODS: There were sixty cases with pituitary prolactin micro-adenoma and 30 cases with large adenoma.Two groups were orally administered bromocriptine,the amount of night began with 1.25 mg,increased 1.25 mg every 3 d,until 2.5 mg,tid.The serum prolactin and pituitary magnetic resonance were detected before treatment and 28 weeks after treatment.RESULTS:The serum prolactin level d...