| 血清25（OH）D测定的液相色谱质谱法 |
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| 引用本文： | 周建烈,陈悦,余琛,李水军. 血清25（OH）D测定的液相色谱质谱法[J]. 中华临床营养杂志, 2011, 19(5): 339-342. DOI: 10.3760/cma.j.issn.1674-635X.2011.05.016 |
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| 作者姓名： | 周建烈 陈悦 余琛 李水军 |
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| 作者单位： | 1. 《今日维生素D》网站, 上海,200234
2. 200031,上海市徐汇区中心医院中心实验室 |
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| 摘 要： | 维生素D缺乏与多种疾病相关,血清25(OH)D水平可以作为维生素D营养状况的客观指标.液相色谱质谱法(LC-MS)是临床营养常规测量25(OH)D的标准方法.本文总结了检测25 (OH) D2和25 (OH)D3的意义,比较了各种25(OH)D的检测方法及其优缺点,介绍了我国采用美国国立标准技术研究院质控品标准的LC-MS法常规检测25(OH)D2和25(OH)D3的情况.
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| 关 键 词： | 维生素D 液相色谱质谱法 25 (OH) D2 25(OH)D3 |
Liquid chromatography-mass spectrometry for measurement of serum 25(OH)D level |
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| ZHOU Jian-lie,CHEN Yue,YU Chen,LI Shui-jun. Liquid chromatography-mass spectrometry for measurement of serum 25(OH)D level[J]. Chinese Journal of Clinical Nutrition, 2011, 19(5): 339-342. DOI: 10.3760/cma.j.issn.1674-635X.2011.05.016 |
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| Authors: | ZHOU Jian-lie CHEN Yue YU Chen LI Shui-jun |
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| Affiliation: | (Vitamin D Today website, Shanghai 200234, China) |
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| Abstract: | Many diseases are associated with vitamin D deficiency.Serum 25 (OH)D levels can serve as objective indicators of the nutritional status of vitamin D.Liquid chromatography-mass spectrometry (LC-MS) method may be applied for routine measurement of 25 ( OH ) D levels in clinical practice.This article reviewed the significance of detecting 25 (OH) D2 and 25 (OH) D3,compared the advantages and disadvantages of different 25 (OH) D measurement methods,and introduced the application of LC-MS method for routine detection of serum 25 (OH) D2 and 25 (OH) D3 levels following the standard by National Institute of Standards and Technology of America. |
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| Keywords: | Vitamin D liquid chromatography-mass spectrometry 25 (OH) D2 25 (OH) D3 |
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