黄芩苷在大鼠体内的药动学研究

 目的：测定黄芩苷的药动学参数，为临床合理用药提供科学依据。方法：采用高效液相色谱法，以电化学检测测定黄芩苷在大鼠体内的药动学参数。结果：黄芩苷在大鼠体内呈二室模型分布，其药动学参数是V_d=2.53L，K_e=4.17h^-1，K₁₂=5.25h^-1，K₂₁=0.63h-^-1，t_1/2=0.16h，α=10.29ng·ml^-1·h^-1，β=0.29ng·ml^-1·h^-1，AUC=1.93μg·h·ml^-1。

Pharmacokinetics of baicaline in rat

OBJECTIVE: To determine parameters of pharmacokinetis in rat and provide a scientific basis for rationalized use of cefmetazole. METHOD: Using the method of HPLC-ECD, we determined pharmacokinetics of baicaline in rat. The conditions were as follows: column, ERC-ODS-1611, 6 mm×100 mm; temperature, 55 ℃; flow phases, 0.1 mol·L^-1 KH₂PO₄, acetic acid, tetrahydrfuran (1 000∶100∶190); flow rate, 0.8 ml·min^-1; volt of detector, +650 mV. RESULTS: The baicaline of injection showed two-compartment in the body of the rat; the parameter of the pharmacokinetion was V_d=2.53 L,Ke=4.17 h^-1,K₁₂=5.25 h^{-1,K₂₁=0.63 h-1,t_1/2=0.16 h,α=10.29 ng·ml-1·h-1,β=0.29 ng·min-1, AUC=1.93 μg·h·ml-1。}