Atrial fibrillation signal organization predicts sinus rhythm maintenance in patients undergoing cardioversion of atrial fibrillation. |
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| Authors: | Fredrik Holmqvist Martin Stridh Johan E P Waktare Anders Roijer Leif S?rnmo Pyotr G Platonov Carl J Meurling |
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| Affiliation: | Department of Cardiology, Lund University Hospital, SE-221 85 Lund, Sweden. fredrik.holmqvist@med.lu.se |
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| Abstract: | AIMS: Electrical remodelling is believed to influence the outcome following cardioversion of patients with persistent atrial fibrillation (AF). However, the results in clinical studies are conflicting. We assessed the hypothesis that non-invasively obtained atrial fibrillatory organization can be used as a predictor of sinus rhythm (SR) maintenance. METHODS AND RESULTS: Fifty-four patients (37 men, age 67+/-11) with persistent AF (median duration 3 months, 1 day to 18 months), without anti-arrhythmic drug treatment, referred for cardioversion were studied. Assessment of the atrial harmonic decay was made by time-frequency analysis of the ECG. At 1-month follow-up, 30 patients had relapsed into AF. The mean harmonic decay at inclusion of those relapsing into AF was 1.5+/-0.3 compared with 1.1+/-0.3 among those maintaining SR (P=0.0004). Using a cut-off value of harmonic decay
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| Keywords: | Atrial fibrillation, Electrophysiology— Clinical, Electrocardiogram, Non-invasive risk assessment tests, Harmonic decay, Cardioversion |
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