血糖波动:糖尿病治疗的新靶点

糖尿病的"血糖代谢紊乱"包括三要素:空腹、餐后血糖升高和血糖波动特征异常.血糖急性波动通过活化氧化应激、内皮功能紊乱、激活凝血系统和炎性反应过程参与糖尿病慢性并发症的进展.因此,控制血糖波动应该是糖尿病治疗策略的一个重要内容,其中胰高血糖素样肽-1(GLP-1)受体激动剂、二肽基肽酶(DPP)-IV抑制剂和超短效胰岛素类似物具有广阔的治疗应用前景.

Glycemic fluctuation: a new target in the treatment of diabetes

Glucose fluctuation should be included in the"dysglycemia" of diabetes in combination with fasting and postprandial hyperglycemia.Glycemic fluctuation produces a cascade of such deleterious met-abolic events as enhanced coagulation activity,dysfunction of endothelium,activation of oxidative stress and inflammation,and induces chronic complications of diabetes.Therefore,lowering postprandial glucose is crocial for diabetic treatment strategy.And glucagon-like peptide-1(GLP-1) receptor agonists(mimetics),DDPⅣ inhibitor and fast-acting insulin analogues are promising choices.