| Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats |
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| 引用本文： | 黄钺华,张敏,王传年,李元平,史景泉,许平庆. Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats[J]. 中国人民解放军军医大学学报, 1989, 0(3) |
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| 作者姓名： | 黄钺华 张敏 王传年 李元平 史景泉 许平庆 |
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| 作者单位： | Departments of Pharmacology and Pathology Third Military Medical College Chongqing，Departments of Pharmacology and Pathology Third Military Medical College Chongqing，Departments of Pharmacology and Pathology Third Military Medical College Chongqing，Departments of Pharmacology and Pathology Third Military Medical College Chongqing，Departments of Pharmacology and Pathology Third Military Medical College Chongqing，Departments of Pharmacology and Pathology Third Military Medical College Chongqing |
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| 摘 要： | Six hours after smoke inhalation injury in rabbits, the permeability of pulmonary vesselsand the aggregation of circulating platelets increased markedly accompanied with apparent patholog-ical changes in the trachea and lungs. Fifteen minutes after smoke inhalation injury in rabbits, an intravenous dose of ginsenosides or ketoprofenwas given to the animals respectively. 6 hours after medication, it was found that both the drugscould significantly alleviate the platelet aggregation, but only ginsenosides could alleviate theaugmentation of pulmonary vascular permeability and the pathological lesions in the trachea andlungs. In those rats injured by smoke inhalation, l hour after an intravenous dose of ginsenosides, theplasma PGI_2 level was elevated and TXA_2/PGI_2 ratio decreased significantly.
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Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats |
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| Huang Yuehua,Zheng Min,Wang Chuannian,Li Yuanping,Shi Jingquan,Xu Pingqing,Departments of Pharmacology and Pathology,Third Military Medical College,Chongqing. Effects of Ginsenosides and Ketoprofen on Smoke Inhalation Injury in Rabbits and Rats[J]. Journal of Medical Colleges of PLA(China), 1989, 0(3) |
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| Authors: | Huang Yuehua Zheng Min Wang Chuannian Li Yuanping Shi Jingquan Xu Pingqing Departments of Pharmacology Pathology Third Military Medical College Chongqing |
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| Abstract: | Six hours after smoke inhalation injury in rabbits, the permeability of pulmonary vessels and the aggregation of circulating platelets increased markedly accompanied with apparent patholog- ical changes in the trachea and lungs. Fifteen minutes after smoke inhalation injury in rabbits, an intravenous dose of ginsenosides or ketoprofen was given to the animals respectively. 6 hours after medication, it was found that both the drugs could significantly alleviate the platelet aggregation, but only ginsenosides could alleviate the augmentation of pulmonary vascular permeability and the pathological lesions in the trachea and lungs. In those rats injured by smoke inhalation, l hour after an intravenous dose of ginsenosides, the plasma PGI_2 level was elevated and TXA_2/PGI_2 ratio decreased significantly. |
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| Keywords: | ginsenosides ketoprofen smoke inhalation injury pulmonary vascular permeability platelet aggregation |
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