Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation |
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| Authors: | J. Smedbråten S. Sagedal A. Åsberg A. Hartmann H. Rollag G. Mjøen M. W. Fagerland S. W. K. Hansen T. E. Mollnes S. Thiel |
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| Affiliation: | 1. Department of Nephrology, Ullev?l Oslo University Hospital, Oslo, Norway;2. Faculty of Medicine, University of Oslo, Oslo, Norway;3. Department of Transplant Medicine, Rikshospitalet Oslo University Hospital, Oslo, Norway;4. Norwegian Renal Registry, Oslo University Hospital, Oslo, Norway;5. School of Pharmacy, University of Oslo, Oslo, Norway;6. Department of Microbiology, Rikshospitalet Oslo University Hospital, Oslo, Norway;7. Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway;8. Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;9. Department of Immunology, Oslo University Hospital Rikshospitalet and K. G. Jebsen IRC, University of Oslo, Oslo, Norway;10. Research Laboratory, Nordland Hospital, Bod?, Norway;11. Faculty of Health Sciences, K. G. Jebsen TREC, University of Troms?, Troms?, Norway;12. Center of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway;13. Department of Biomedicine, Aarhus University, Aarhus, Denmark |
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| Abstract: | Kidney transplanted patients still have significantly higher mortality compared with the general population. The innate immune system may play an important role during periods, with suppression of the adaptive immune system. In the present study, two soluble pattern recognition molecules of the innate immune system were investigated, collectin liver 1 (CL‐L1) and collectin kidney 1 (CL‐K1). Potential associations of their pretransplant levels and long‐term graft and recipient survival were examined. The levels of CL‐L1 and CL‐K1 were measured at the time of transplantation in 382 patients (≥17 years) transplanted in 2000–2001. The cohort was subsequently followed until December 31, 2014. Data on patient and graft survival were obtained from the Norwegian Renal Registry. Both high CL‐L1 (≥376 ng/mL) and high CL‐K1 (≥304 ng/mL) levels were significantly associated with overall mortality in multivariate Cox analyses with hazard ration (HR) 1.50, 95% confidence interval (CI) 1.09–2.07, p = 0.013 and HR 1.43, 95% CI 1.02–1.99, p = 0.038, respectively. Moreover, high CL‐K1 levels were significantly associated with cardiovascular mortality. No association between measured biomarkers and death‐censored graft loss was found. Finally, there was a significant correlation between these two collectins, r = 0.83 (95% CI 0.80–0.86). In conclusion, CL‐L1 and CL‐K1 were significantly associated with mortality in kidney transplant recipients. |
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| Keywords: | clinical research / practice basic (laboratory) research / science kidney transplantation / nephrology biomarker complement biology graft survival innate immunity patient survival |
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