| 野黄芩甙元对糖尿病大鼠主动脉的影响 |
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| 引用本文： | Zhu BH,Guan YY,He H,Lin MJ. 野黄芩甙元对糖尿病大鼠主动脉的影响[J]. Acta pharmacologica Sinica, 2000, 21(4): 353-356 |
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| 作者姓名： | Zhu BH Guan YY He H Lin MJ |
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| 作者单位： | 中山医科大学药理教研室,中山医科大学药理教研室,中山医科大学药理教研室,CMB Visiting Scholar from Department of Physiology,Pujian Medical University 广州 510089 中国,广州 510089 中国,广州 510089 中国 |
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| 基金项目： | Project supported by the Returned Scholar Foundation of the National Education Committee of China,the National Natural Science Foundation (№ 39770858) and the Post-doctoral Foundation of China |
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| 摘 要： | 目的：研究野黄芩甙元对糖尿病大鼠血管合并症的预防作用。方法：利用平滑肌条离体研究装置。结果：在第六周的糖尿病大鼠主动脉：1）乙酰胆碱引起的内膜依赖性舒张作用较对照明显减弱（P＜0．01）;2）苯肾上腺素引起的收缩反应较对照明显增加,最大收缩增加约40％（P＜0．01）;3）糖尿病大鼠服用含0．5％的野黄芩甙元的饮水后,乙酰胆碱引起的内膜依赖性舒张作用较糖尿病组明显增加（P＜0．01）。但是,苯肾上腺素引起的收缩反应增加更显著,最大收缩较对照加约80％（P＜0．01）。结论：野黄芩甙元对糖尿病引起的血管内膜功能损害有防护作用,也可增强苯肾上腺素引起的收缩。
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| 关 键 词： | 野黄芩甙元 糖尿病 胸主动脉 血管内皮 苯肾上腺素 乙酰胆碱 链佐星 |
Effects of Scutellarein on diabetic rat aorta |
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| Zhu B H,Guan Y Y,He H,Lin M J. Effects of Scutellarein on diabetic rat aorta[J]. Acta pharmacologica Sinica, 2000, 21(4): 353-356 |
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| Authors: | Zhu B H Guan Y Y He H Lin M J |
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| Affiliation: | Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, China. sszhu@gzsums.edu.cn |
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| Abstract: | AIM: To study the effect of Scutellarein (Scu) on the diabetic rat aorta. METHODS: Contractile responses to phenylepherine and endothelium-dependent relaxation responses to acetylcholine (ACh) in rat aorta were investigated after streptozocin-induced 6-wk diabetes, Scu-treat-ed streptozocin-induced diabetes, and in age-matched control in vitro. RESULTS: 1) Endothelium-dependent relaxation to ACh in diabetic rats was decreased (P <0.01) compared with age-matched control. 2) Contractile responses to phenylepherine were increased ( P < 0.01) in diabetic rats. 3) The dietary supplement of 0.5 % Scu starting from 1-wk diabetes induction prevented endothelial dysfunction (P < 0.01), but the contractile responses to phenylepherine were further increased. CONCLUSION: Scu prevented vascular endothelial dysfunction in diabetic rats, and also potentiated the contraction induced by phenylepherine |
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| Keywords: | Scutellarein experimental diabetes mellitus thoracic aorta vascular endothelium phenyle- pherine acetylcholine streptozocin vasoconstriction vasodilation |
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