| 6种黄酮类化合物对离体肝储脂细胞增殖的影响(英文) |
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| 引用本文： | Zhang M,Zhang JP,Ji HT,Wang JS,Qian DH. 6种黄酮类化合物对离体肝储脂细胞增殖的影响(英文)[J]. Acta pharmacologica Sinica, 2000, 21(3): 253-256 |
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| 作者姓名： | Zhang M Zhang JP Ji HT Wang JS Qian DH |
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| 作者单位： | 第二军医大学药学院生化药学教研室,第二军医大学药学院生化药学教研室,第二军医大学药学院生化药学教研室,第二军医大学药学院生化药学教研室,第二军医大学药学院生化药学教研室 上海 200433 中国,上海 200433 中国,上海 200433 中国,上海 200433 中国,上海 200433 中国 |
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| 基金项目： | Project supported by the National Natural Science Foundation of China, No 39670837. |
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| 摘 要： | 目的:研究黄颜木素、槲皮素、芹菜素、根皮素、橙皮素和查耳酮对血清、巨噬细胞上清和血小板源生生长因子刺激的HSC-T6细胞增殖的影响。方法:结晶紫染色法测定细胞增殖。结果:黄颜木素、槲皮素、芹菜素、根皮素、橙皮素和查耳酮(6.25-50μmol/L)以剂量依赖方式显著抑制血清、巨噬细胞上清和血小板源生生长因子诱导的HSC-T6细胞增殖。结论:黄颜木素、槲皮素、芹菜素、根皮素、橙皮素和查耳酮具有抑制肝储脂细胞增殖的作用。
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| 关 键 词： | 黄颜木素 槲皮素 芹菜素 根皮素 橙皮素 查耳酮 细胞分裂 巨噬细胞 血小板源生生长因子 |
Effect of six flavonoids on proliferation of hepatic stellate cells in vitro |
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| Zhang M,Zhang J P,Ji H T,Wang J S,Qian D H. Effect of six flavonoids on proliferation of hepatic stellate cells in vitro[J]. Acta pharmacologica Sinica, 2000, 21(3): 253-256 |
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| Authors: | Zhang M Zhang J P Ji H T Wang J S Qian D H |
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| Affiliation: | Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. |
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| Abstract: | AIM: To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperetin, and chalcone) on proliferation of hepatic stellate cell (HSC-T6 cells). METHODS: Cell proliferation was measured by crystal violet staining assay. RESULTS: Fisetin, quercetin, apigenin, phloretin, hesperetin, chalcone (6.25-50 mumol.L-1) inhibited the proliferation of HSC-T6 cells stimulated by serum, macrophage conditioned medium (MCM) and platelet-derived growth factor (PDGF) in a concentration-dependent manner. In the MCM-stimulated proliferation experiment, their IC50 were 21.48, 18.52, 19.75, 22.32, 30.32, and 30.85 mumol.L-1, respectively. In the PDGF-stimulated proliferation experiment, their IC50 were 9.47, 9.48, 9.25, 12.25, 25.22, and 30.40 mumol.L-1, respectively. CONCLUSION: The six flavonoids inhibited the proliferation of hepatic stellate cells. |
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| Keywords: | fisetin quercetin apigenin phloretin hesperetin chalcone cell division macrophages platelet-derived growth factor |
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