Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases |
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Authors: | Campidelli Cristina Sabattini Elena Piccioli Milena Rossi Maura De Blasi Donatella Miraglia Eustachio Rodriguez-Abreu Delvys Franscini Leda Leoncini Bertoni Francesco Mazzucchelli Luca Cavalli Franco Zucca Emanuele Pileri Stefano A |
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Affiliation: | Institute of Hematology and Clinical Oncology L. and A. Seràgnoli, Unit of Hematopathology, Bologna University School of Medicine, Bologna, Italy. cristina.campidelli@virgilio.it |
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Abstract: | We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor gamma and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed. |
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Keywords: | Composite lymphoma Peripheral T-cell lymphoma B-cell chronic lymphocytic leukemia/B-cell small lymphocytic lymphoma EBV |
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