High CTG repeat number in nodular thyroid tissue from a myotonic dystrophy patient. |
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| Authors: | C Daumerie N Lannoy J P Squifflet G Verellen and C Verellen-Dumoulin |
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| Institution: | Service d''Endocrinologie, Cliniques Universitaires St Luc, Brussels, Belgium. |
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| Abstract: | CTG triplet expansion was studied in lymphocytes and thyroid tissue in a patient with myotonic dystrophy (DM) and associated thyroid nodular disease. An approximately 7 fold larger amplification was found in abnormal thyroid tissue compared to lymphocytes, suggesting that anomalies in the putative DM kinase gene might contribute to thyroid dysfunction. |
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