IL-6、IL-8在新生儿感染中的改变

目的探讨血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）水平与新生儿感染之间的关系.方法采用酶联免疫吸附试验（ELISA）和免疫比浊法检测45例新生儿感染患儿及20例正常健康儿血清中IL-6、IL-8 和C-反应蛋白（CRP）的含量.结果新生儿感染急性期IL-6、IL-8和CRP水平较对照组明显升高（P《0.001）, 败血症组较非败血症组明显升高（P《0.001）, 恢复期与正常水平差异无显著性（P》0.05）;感染急性期IL-6、IL-8和CRP水平呈正相关性（P《0.01）.结论 IL-6、IL-8参与了炎症反应过程, 其水平的高低可反映疾病的严重程度,可作为感染性疾病早期诊断的重要检测指标.

The Clinical Significance of Serum IL-6,IL-8 and CRP Levels in Neonate With Asthma

Objective To explore the clinical significance of IL-6 and IL-8 in neonatal infection.Methods The serum levels of IL-6,IL-8 and C-reactive protein(CRP) were detected by ELISA and Immunity in 45 neonates with infection and in 20 healthy controls.Results The serum IL-6,IL-8 and CRP levels in neonates with infection at the acute period of disease were significantly higher than those in controls(P<0.001);serum IL-6,IL-8 and CRP levels in neonates with sepsis group were significantly higher than those in non-sepsis group(P<0.001).No difference of those results were found between newborns in infectious recovery period and control group(P>0.05).Serum IL-6,IL-8 had positive correlation with CRP in acute period of disease(P<0.01).Conclusion The IL-6,IL-8 are involved in neonate infection,and had correlation with degree of infection.Inflammatory cytokines might be sensitive markers of diagnosis for neonatal infection.