Risk factors for long-term mortality of Staphylococcus aureus bacteremia |
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Authors: | D. Yahav S. Yassin H. Shaked E. Goldberg J. Bishara M. Paul L. Leibovici |
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Affiliation: | 1.Unit of Infectious Diseases,Rabin Medical Center, Beilinson Hospital,Petah-Tikva,Israel;2.Sackler Faculty of Medicine,Tel Aviv University,Ramat-Aviv,Israel;3.Department of Medicine D,The Chaim Sheba Medical Center,Tel Hashomer,Israel;4.Department of Medicine F,Rabin Medical Center, Beilinson Hospital,Petah-Tikva,Israel;5.Unit of Infectious Diseases,Rambam Hospital,Haifa,Israel;6.Department of Medicine E,Rabin Medical Center, Beilinson Hospital,Petah-Tikva,Israel |
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Abstract: | Staphylococcus aureus bacteremia (SAB) is a fatal disease. We aimed to describe risk factors for long-term mortality with SAB. We analyzed data from a retrospectively collected database including 1,692 patients with SAB. We considered variables of infection and background conditions for the analysis of long-term survival. The Kaplan–Meier procedure was used for analysis of long-term survival. Variables significantly associated with mortality were analyzed using a Cox regression model. We included 1,692 patients in the analysis. Patients were followed for up to 22 years. Within one year, 62% of patients died and within 5 years 72% died. A total of 82% of patients aged 65 years and older died within 5 years. Independent predictors of long-term mortality were older age (Hazard ratio 1.029, 95% confidence interval 1.022–1.036), female gender (HR 1.302, 95% CI 1.118–1.517), pneumonia or primary/ unknown source of infection (HR 1.441, 95% CI 1.230–1.689), dementia (HR 1.234, 95% CI 1.004–1.516), higher Charlson score (HR 1.155, 95% CI 1.115–1.196), shock at onset (HR 1.776, 95% CI 1.430–2.207) and arrival to hospitalization from an institution (HR 1.319, 95% CI 1.095–1.563). Long-term survival of patients older than 65 years and of women with SAB is severely curtailed. |
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