165例乙型肝炎病毒携带产妇乳汁HBV-DNA检测及临床分析

目的探讨乙型肝炎病毒(HBV)携带产妇乳汁中HBV携带状况以及HBV携带母乳喂养的安全性。方法选择HBV携带产妇165例(肝功能均正常)及30例HBV标志物(HBVM)阴性产妇,分别采用酶联免疫吸附试验(ELISA)检测产妇血清HBVM和荧光定量聚合酶链反应(FQ-PCR)检测产妇初乳HBV-DNA,并对结果进行综合分析。结果(1)165例HBVM阳性组产妇乳汁HBV-DNA阳性53例(32.12%),对照组30例中无1例产妇乳汁HBV-DNA阳性;(2)165例HBV携带产妇中,母血HBsAg、HBeAg、抗-HBc(+)53例产妇乳汁中HBV-DNA阳性33例(62.3%),HBsAg、抗-HBe、抗-HBc(+)85例产妇乳汁中HBV-DNA阳性9例(10.6%),HBsAg、HBeAg(+)7例产妇乳汁中HBV-DNA阳性5例(71.4%),HBsAg、抗-HBc(+)13例产妇乳汁中HBV-DNA阳性4例(30.8%),HBsAg(+)7例产妇乳汁中HBV-DNA阳性2例(28.6%);(3)165例HBV携带产妇中,母血HBeAg(+)60例产妇乳汁中HBV-DNA阳性38例(63.3%),HBe...