| 度洛西汀与文拉法辛对首发抑郁症疗效的对照研究 |
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| 引用本文： | 钱敏才,林敏,沈鑫华,钟华,朱毅平,杨剑虹. 度洛西汀与文拉法辛对首发抑郁症疗效的对照研究[J]. 上海精神医学, 2008, 20(5): 292-294 |
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| 作者姓名： | 钱敏才 林敏 沈鑫华 钟华 朱毅平 杨剑虹 |
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| 作者单位： | 浙江省湖州市第三人民医院神经症科,313000 |
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| 摘 要： | 目的观察固定剂量度洛西汀与文拉法辛对首发抑郁症患者的疗效和安全性。方法73例首发抑郁症患者随机分为度洛西汀组（36例）和文拉法辛组（37例），治疗剂量分别为60mg／d和150mg／d，观察8周。用汉密尔顿抑郁量表（HAMD17）和蒙哥马利抑郁量表（MADRS）评定疗效，不良反应量表（TESS）评定不良反应和安全性。结果度洛西汀组31例和文拉法辛组30例完成8周的观察。至第8周末两组的有效率和临床痊愈率分别为77．4％（24／31）、83．3％（25／30）和48．4％（15／31）、53．3％（16／30），差异无统计学意义。治疗第1周末，文拉法辛组起效率（80．0％）高于度洛西汀组（41．9％）。度洛西汀组主要不良反应为食欲减退、恶心、心动过速、头痛、震颤、口干和便秘，与文拉法辛组相似。结论度洛西汀对首发抑郁症患者安全有效，与文拉法辛相似。
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| 关 键 词： | 度洛西汀 文拉法辛 首发抑郁症 对照研究 |
Comparative study of duloxetine with venlafaxine in the treatment of first episode depression |
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| Qian Mincai,Lin Min,Shen Xinhua,Zhong Hua,Zhu Yiping,Yang Jianhong. Comparative study of duloxetine with venlafaxine in the treatment of first episode depression[J]. Shanghai Archives of Psychiatry, 2008, 20(5): 292-294 |
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| Authors: | Qian Mincai Lin Min Shen Xinhua Zhong Hua Zhu Yiping Yang Jianhong |
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| Affiliation: | Qian Mincai,Lin Min,Shen Xinhua,Zhong Hua,Zhu Yiping,Yang Jianhong. The third Municipal Hospital of Huzhou,Zhejiang Province,Huzhou 313000 |
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| Abstract: | Objective: To compare the efficacy and safety of fixed dose of duloxetine with venlafaxine in treatment of first episode depression. Methods: Seventy-three patients with first episode of depression were randomly assigned to duloxetine group and venlafaxine group. Thirty-six patients received duloxetine 60mg/d while 37 were treated with venlafaxine 150mg/d for 8 weeks. The efficacy was assessed by scores of Hamilton Rating Scale for Depression(17-items)(HAMD17) and Montgomery-Asberg Depression Rating Scale( ... |
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| Keywords: | Duloxetine Venlafaxetine First episode depression Controlled study |
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