Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats |
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| Authors: | Mehrdad Roghani Tourandokht Baluchnejadmojarad |
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| Institution: | 1. School of Medicine, Shahed University, Tehran, Iran;2. Department of Anatomy and Pathology, School of Medicine, Shahed University, Tehran, Iran;3. Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;4. Neurophysiology Research Center, Department of Physiology, Shahed University, Tehran, Iran |
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| Abstract: | Background and objective: Green tea catechins including epigallocatechin-3-gallate (EGCG) could exert beneficial health effects to ameliorate metabolic diseases. The effect of chronic administration of EGCG was evaluated on serum glucose and lipid profile and hepatic lipid peroxidation in streptozotocin (STZ)-diabetic rats. Materials and methods: Rats received EGCG 25 mg/kg/day for 8 weeks 1 week after diabetes induction. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels and MDA level and SOD activity in hepatic tissue were spectrophotometrically measured. Results: Treatment of diabetic rats with EGCG produced a hypoglycemic effect and there were appropriate changes regarding serum lipids in treated diabetic group. Meanwhile, EGCG treatment attenuated the increased MDA content and reduced activity of SOD in liver. Conclusion: Chronic treatment of diabetic rats with EGCG could prevent abnormal changes in blood glucose and lipid profile and attenuat hepatic lipid peroxidation. |
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