Verbal fluency as a possible predictor for psychosis |
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| Authors: | H.E. Becker D.H. Nieman P.M. Dingemans J.R. van de Fliert L. De Haan D.H. Linszen |
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| Affiliation: | 1. Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Hawthorn, Australia;2. Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School, Alfred Hospital, Melbourne, Australia;3. St. Vincent''s Mental Health Service, St. Vincent''s Hospital, Melbourne, Australia |
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| Abstract: | BackgroundNeurocognitive abnormalities are prevalent in both first episode schizophrenia patients and in ultra high risk (UHR) patients.AimTo compare verbal fluency performance at baseline in UHR in patients that did and did not make the transition to psychosis.MethodBaseline verbal fluency performance in UHR-patients (n = 47) was compared to match first episode patients (n = 69) and normal controls (n = 42).ResultsVerbal fluency (semantic category) scores in UHR-patients did not differ significantly from the score in first episode schizophrenia patients. Both the UHR group (p < 0.003) and the patient group (p < 0.0001) performed significantly worse than controls. Compared to the non-transition group, the transition group performed worse on verbal fluency, semantic category (p < 0.006) at baseline.ConclusionsVerbal fluency (semantic category) is disturbed in UHR-patients that make the transition to psychosis and could contribute to an improved prediction of transition to psychosis in UHR-patients. |
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