Neural correlates of inhibitory deficits in depression |
| |
| Authors: | Fanny Eugène Jutta Joormann Rebecca E Cooney Lauren Y Atlas Ian H Gotlib |
| |
| Institution: | 1. Department of Psychology, Concordia University, Montréal, Québec, Canada;2. Department of Psychology, University of Miami, Coral Gables, FL, USA;3. Department of Psychology, Stanford University, Stanford, CA, USA;4. Department of Psychology, Columbia University, New York, NY, USA;1. Division of Child and Adolescent Psychiatry, University of California, San Francisco, San Francisco;2. Department of Psychiatry, University of California, San Francisco, San Francisco;3. Veterans Affairs San Diego Health Care System, University of California, San Francisco, San Francisco;4. Department of Psychiatry, University of California, San Diego, La Jolla;5. Rady Children’s Hospital, San Diego, California;6. Department of Psychiatry, University of Colorado, Denver, Colorado;1. Department of Psychiatry, Division of Child and Adolescent Psychiatry, and Weill Institute for Neurosciences, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA, USA;2. Department of Psychology, Stanford University, Stanford, CA, USA;3. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;4. Neurosciences Program, Stanford University, Stanford, CA, USA;5. Department of Radiology & Biomedical Imaging, University of California, San Francisco, 1700 4th St., San Francisco, CA, USA;6. Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA;7. Veterans Affairs San Diego Health Care System, La Jolla, CA, USA;1. Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;2. Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China;3. Rehabilitation College of Capital Medical University, China Rehabilitation Research Center, Beijing 100068, China;4. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China;5. Department of Psychology, Queens College, The City University of New York, Queens, New York 11367, USA;1. Department of Neuroscience, Faculty of Medicine, University of Geneva, Switzerland;2. Cyclotron Research Center, University of Liège, Belgium;3. Department of Psychiatry, Geneva University Hospital, Switzerland;4. Department of Psychiatry and Mental Health, Strasbourg University Hospital, University of Strasbourg, INSERMu1114, France;5. Department of Clinical Neuroscience, Geneva University Hospital, Switzerland;1. Department of Psychology and Neuroscience, Box 90086, Duke University, Durham, NC 27708, USA;2. Department of Psychiatry and Behavioral Sciences, Box 3026, Duke University Medical Center, Durham, NC 27710, USA;3. Duke Interdisciplinary Initiative in Social Psychology, Erwin Mill Building, 2024 West Main Street, Durham, NC 27705, USA |
| |
| Abstract: | The present study used functional magnetic resonance imaging to examine neural correlates of inhibitory dysfunction in individuals diagnosed with major depressive disorder (MDD). Twelve MDD participants and 12 never-depressed controls completed the negative affective priming (NAP) task in the scanner. Results indicated that, in depressed participants, increased activation in the rostral anterior cingulate cortex (rACC) is associated with inhibition of negative, but not positive, words; in contrast, in nondepressed participants, inhibition of positive, but not negative, words is associated with increased activation in the rACC. These findings indicate that abnormalities in neural function, especially in the rACC, may underlie difficulties experienced by depressed individuals in inhibiting negative thoughts. These results underscore the importance of continuing to examine the relation between cognitive and neural functioning in depression in order to gain a broader and more integrative understanding of this disorder. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
