Gastric healing effect of melatonin against different gastroinvasive agents in cholestatic rats |
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| Authors: | Leila Moezi Somaye Nasiripoor Vida Mohajer Mona Maghsoodi Morteza Samini Ahmad R Dehpour |
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| Institution: | 1. Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Institute of Pathogen Biology/Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine, Shandong University, Jinan 250012, China;2. Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University, Jinan 250012, China;3. Department of Pathology, Jinan Central Hospital, Jinan 250013, China;1. School of Earth Sciences & Key Laboratory of Mineral Resources in Western China (Gansu Province), Lanzhou University, Lanzhou 730000, China;2. State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, CAS, Nanjing 210008, China;1. Department of Physiology, Development and Neuroscience and;2. British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom;;3. Department of Clinical Sciences, Lund University, Lund, Sweden; and;4. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;1. Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China;2. MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China;3. Institute of Animal Husbandry and Veterinary Science, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Anhui Academy of Agricultural Sciences, Hefei, 230001, China |
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| Abstract: | Background and objective: The frequency of gastrointestinal ulceration is higher in jaundiced patients than in healthy population. The aim of this study was to assess the effect of pretreatment with melatonin, a potent scavenger of reactive oxygen species, on stress-induced gastric ulcers of cholestatic rats. Materials and methods: Cholestasis was induced by surgical ligation of bile-duct and sham-operated rats served as sham animals. The animals received saline or melatonin (1, 3 or 10 mg/kg) before stress induction. Three different types of gastroinvasive agents including ethanol, indomethacin or water immersion were used as stress agents to induce gastric ulceration. Results: Gastric mucosal damage induced by different gastroinvasive agents was significantly greater in bile-duct-ligated rats than in sham ones. Melatonin was protective against ethanol-, indomethacin- and water immersion-induced gastric damage in bile-duct-ligated and sham rats, dose-dependently, but the protective effect of melatonin was greater in cholestatic rats than sham rats in all three different series of experiments. Conclusions: In conclusion, pretreatment of rats with melatonin protected gastric mucosa of cholestatic rats more effectively than the sham ones possibly by a mechanism involving the scavenging of free radicals. |
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