Roles of fibrinolytic system components in the nervous system |
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| Authors: | Nobuo Nagai Osamu Matsuo |
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| Institution: | 1. Section of Plastic Surgery, University of Michigan Health Systems, Ann Arbor, MI;2. Department of Surgery, Saint Joseph Mercy Hospital, Ann Arbor, MI;1. Department of Otolaryngology Head & Neck Surgery, Beijing Chaoyang Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing, PR, China;2. Clinic of Beijing Branch, China Southern Airlines Co., Ltd., PR, China;1. Centre Hospitalier du Valais Romand (CHVR), Sierre, Switzerland;2. Center for Hand Surgery and Therapy, Geneva, Switzerland;1. Vanderbilt University School of Medicine, Nashville, Tennessee;2. Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee;3. Department of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee;4. Institute for Neuroscience, School of Biological Sciences, University of Texas at Austin, Austin, Texas |
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| Abstract: | Recent studies have remarkably clarified the physiological roles of fibrinolytic system components on memory formation, neuronal plasticity, neuronal migration, neuronal cell death and axonal regeneration, together with their pathophysiological roles in ischemic stroke, intracerebral hemorrhage and Alzheimer disease in the central nervous system. Fibrinolytic system components also have various roles in the peripheral and autonomic nervous system, not only under physiological conditions but also under pathophysiological conditions. In these roles, fibrinolytic system components work not only through the extracellular proteolytic cascade but also through activation of their own receptors. This paper reviews the roles of fibrinolytic system components in the nervous system. |
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