White matter connectivity and psychosis in ultra-high-risk subjects: A diffusion tensor fiber tracking study |
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| Authors: | Bart D Peters Peter M Dingemans Nienke Dekker Jorik Blaas Erik Akkerman Therese A van Amelsvoort Charles B Majoie Gerard J den Heeten Don H Linszen Lieuwe de Haan |
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| Institution: | 1. Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany;2. Medical Physics Group, Institute for Diagnostic and Interventional Radiology (IDIR), Jena University Hospital, 07743 Jena, Germany;3. Department of Neurology, Jena University Hospital, 07743 Jena, Germany;1. Department of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan;2. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Melbourne, Australia;3. Melbourne School of Engineering, The University of Melbourne, Melbourne, Australia;4. Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan;5. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan;6. Department of Social Medicine, Toho University School of Medicine, Tokyo, Japan;7. Department of Radiology, Toho University School of Medicine, Tokyo, Japan |
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| Abstract: | This study assessed with diffusion tensor imaging (DTI) whether ultra-high-risk subjects who later develop a psychotic disorder (UHR-P) show abnormalities in association white matter fiber tracts as compared to UHR subjects who do not convert to psychosis (UHR-NP) and healthy controls. Participants comprised 17 male UHR subjects and 10 male healthy controls, who received baseline DTI scans before clinical follow-up. The uncinate and arcuate fasciculi, anterior and dorsal cingulate, and subdivisions of the corpus callosum were calculated and visualized, and tract-specific measurements were performed. At 24-month follow-up seven UHR subjects had developed a first psychotic episode. Fractional anisotropy in baseline DTI scans, including left-right asymmetry measures, did not differ between the groups. Thus, DTI measures of these association white matter tracts were not biological markers of psychosis in our UHR sample. Abnormalities of these fiber tracts may develop around or after onset of psychosis. However, further DTI studies in UHR subjects are needed in larger samples. |
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