CREB在食管鳞癌组织中的表达及其临床意义

目的：研究环磷腺苷效应元件结合蛋白（CREB）在食管鳞状细胞癌（ESCC）组织中的表达及其与患者临床特征、预后之间的关系。方法：选取2010年1—12月在河北医科大学第四医院就诊的60例ESCC患者癌组织及癌旁组织，采用Western blot及免疫组化技术检测组织中CREB蛋白的表达水平，并分析其与临床病理指标及患者预后之间的关系。结果：ESCC组织中CREB表达水平较癌旁组织明显升高（P < 0.01）。组织中CREB高表达的患者往往瘤组织较大、临床分期较晚、更易发生淋巴结转移，同时患者5年总生存率较低而累积复发率较高（P < 0.05）。结论：ESCC组织中CREB表达水平明显升高，且高表达CREB的患者往往提示临床进展及较差预后。因此，CREB具有成为ESCC相关肿瘤标志物的潜力。

Expression and clinical significance of CREB in esophageal squamous cell carcinoma tissues

OBJECTIVE: To study the expression of cAMP-response element binding protein (CREB), in esophageal squamous cell carcinoma (ESCC) tissues,and its relationship with clinical characteristics and prognosis of the patients. METHODS: Samples of tumor tissues and paraplastic tissues were collected from 60 cases of the ESCC patients from January to December,2010. Expression of CREB in both tissues and their relationships with the clinical feathers of the patients were analysed by using Western blotting and Immunohistochemical assays. RESULTS: The tumor tissues showed significantly increased expression of CREB protein,compared with the paraplastic tissues (P < 0.01). Among patients,those with higher CREB expression tended to have large tumors,later clinical stages,higher lymph node metastasis and shorter five-year overall survival rate with higher cumulative recurrence rate (P < 0.05). CONCLUSION: The ESCC tissues showed significantly elevated expression of CREB protein. Furthermore,the patients with higher CREB expression in tumor tissues frequently had worse clinical outcomes and poorer prognoses. Therefore,CREB has the potential to be an ESCC-associated tumor marker.