| 脑微出血与阿尔茨海默病关系的研究进展 |
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| 引用本文： | 廖艺斐,张慧,邹良玉. 脑微出血与阿尔茨海默病关系的研究进展[J]. 中国卒中杂志, 2021, 16(4): 327-330. DOI: 10.3969/j.issn.1673-5765.2021.04.002 |
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| 作者姓名： | 廖艺斐 张慧 邹良玉 |
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| 作者单位： | 深圳 518020暨南大学第二临床医学院（深圳市人民医院,南方科技大学第一附属医院）神经内科 |
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| 基金项目： | 广东省重点领域研发计划2018-2019年度“脑科学与类脑研究”重大科技专项项目(2018B030336001)。 |
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| 摘 要： | 脑微出血（cerebral microbleeds,CMBs）是直径为2～10 mm的圆形或椭圆形低密度病变,病灶周围无水肿,经T2*梯度回波或SWI检查可以被发现,是脑小血管病的一种病理改变。随着影像学技术的发展,CMBs在阿尔茨海默病（Alzheimer’s disease,AD）中的检出率不断升高。AD患者CMBs发生率高于健康人群及痴呆症患者,且主要分布在脑叶。CMBs可以通过参与颅内淀粉样变性和神经元变性,与载脂蛋白E基因产生关联及影响血脑屏障等方式在AD疾病进展中发挥作用。
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| 关 键 词： | 脑微出血 阿尔茨海默病 认知功能 |
| 收稿时间： | 2021-02-03 |
Progress of Relationship between Cerebral Microbleeds and Alzheimer's Disease |
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| LIAO Yi-Fei,ZHANG Hui,ZOU Liang-Yu. Progress of Relationship between Cerebral Microbleeds and Alzheimer's Disease[J]. Chinese Journal of Stroke, 2021, 16(4): 327-330. DOI: 10.3969/j.issn.1673-5765.2021.04.002 |
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| Authors: | LIAO Yi-Fei ZHANG Hui ZOU Liang-Yu |
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| Affiliation: | (Department of Neurology,The Second Clinical Medical College of Jinan University,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen 518020,China) |
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| Abstract: | Cerebral microbleed(CMB)is a circular or elliptical low-density lesion with a diameter of 2-10 mm,with no edema around the lesion,which can be found by T2*GRE or SWI.CMB is a pathological change of cerebral small vessel disease.With the development of imaging technology,the detection rate of CMB in Alzheimer’s disease(AD)is increasing.The incidence of CMBs in AD patients is higher than that in the healthy and dementia patients,and the CMBs in AD patients mainly located in brain lobes.CMBs play a role in the progression of AD by involving intracranial amyloidosis and neuronal degeneration,being associated with APOE gene,and affecting the blood-brain barrier. |
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| Keywords: | Cerebral microbleed Alzheimer’s disease Cognitive function |
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