Stress,genetics and epigenetic effects on the neurobiology of suicidal behavior and depression |
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| Authors: | JJ Mann DM Currier |
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| Institution: | 1. Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada;2. Faculty of Medicine, University of Toronto, Canada;3. Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada;4. Institute of Medical Science, University of Toronto, Canada;5. Laboratory Medicine and Pathobiology, University of Toronto, Canada |
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| Abstract: | Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms. |
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