| Akt1和ARK5在乳腺癌中的表达及临床病理意义 |
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| 引用本文： | 史圆圆,吴建农,路名芝,王坤. Akt1和ARK5在乳腺癌中的表达及临床病理意义[J]. 诊断病理学杂志, 2021, 0(3): 189-193 |
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| 作者姓名： | 史圆圆 吴建农 路名芝 王坤 |
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| 作者单位： | 江苏大学附属医院病理科;江西省人民医院病理科;江苏大学附属医院甲乳外科 |
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| 基金项目： | 江西省卫生厅科技计划(20113015)。 |
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| 摘 要： | 目的 探讨Akt1和ARK5在乳腺癌组织中表达与临床病理意义.方法 回顾性分析88例乳腺癌临床病理资料,将其肿瘤组织制成组织芯片,并用免疫组化EnVision两步法检测Akt1和ARK5在乳腺癌组织中的表达,取10例癌旁组织作对照.结果88例乳腺癌中Akt1阳性表达率是77.3％(68/88),乳腺癌中Akt1表达与淋...
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| 关 键 词： | 乳腺癌 Akt1 ARK5 |
Expression of Akt1 and ARK5 in breast cancer and its clinical significance |
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| SHI Yuan-yuan,WU jian-nong,LU Ming-zhi,WANG Kun. Expression of Akt1 and ARK5 in breast cancer and its clinical significance[J]. Chinese Journal of Diagnostic Pathology, 2021, 0(3): 189-193 |
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| Authors: | SHI Yuan-yuan WU jian-nong LU Ming-zhi WANG Kun |
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| Affiliation: | (Department of Pathology,the Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China;Department of Pathology,Jiangxi Provincil People’s Hospital,Nanchang 330000,China;Department of Thyroid and Breast Surgery,the Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China) |
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| Abstract: | Purpose To investigate the significance of the expression of Akt1 and ARK5 in breast cancer.Methods The clinicopathological characteristics of 88 cases of breast cancer were retrospectively reviewed.Immunohistochemistry method was used to examine the expression of Akt1 and ARK5 in breast cancer and another 10 cases of adjacent tissues as controls.Results Akt1 expression in breast cancer was 77.3%(68/88).The expression of Akt1 was closely related to lymph node and TNM stage in breast cancer(P<0.05).ARK5 expression in breast cancer was 48.9%(43/88).The expression of ARK5 was closely related to lymph node and tumor diameter in breast cancer(P<0.05).Additionally,Akt1 expression correlated positively with ARK5 in breast cancer(r=0.308,P<0.05).Conclusions Akt1 and ARK5 are expected to be used as important indicators to evaluate the clinical pathological stage of breast cancer. |
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| Keywords: | Breast cancer Akt1 ARK5 |
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