Environment and the serotonergic system |
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Authors: | L. Oreland N. Nordquist J. Hallman J. Harro K.W. Nilsson |
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Affiliation: | 1. Ifremer, Laboratoire d''Écotoxicologie, L''Houmeau/Nantes, France;2. Littoral Environnement et Sociétés (LIENSs), CNRS-Université de La Rochelle, UMRi 7266, 2 rue Olympe de Gouges, F17042 La Rochelle Cedex 01, France;3. Université de Bordeaux (EPOC, LPTC, UMR CNRS 5805), 351 Cours de la Libération, F33405 Talence Cedex, France;4. INRA, Laboratoire de Physiologie et Génomique des Poissons, Campus Beaulieu, 35042 Rennes Cedex, France;1. Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia;2. Laboratory of Molecular Cell Biology, Katholieke Universiteit Leuven, Heverlee-Leuven, Flanders, Belgium;3. Faculty of Biology, University of Belgrade, Belgrade, Serbia;4. Department of Physiology, Institute for Biological Research, University of Belgrade, Belgrade, Serbia;5. Institute of Entomology, Biology Centre of the Czech Academy of Sciences, ?eské Budějovice, Czech Republic |
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Abstract: | In summary, genetics, as well as foetal and early life environmental factors shape the size or capacity of our monoamine systems, of which the serotonergic one might play a leading role. Those constitutional properties then form the biological basis for personality traits, such as impulsiveness and “sensation seeking”, which interact with psychosocial settings and life events to form a pattern of reactivity to a current life event or psychosocial situation, shown as a high or low order of magnitude of gene-environment interaction. In the present paper emphasis is put on the role of genotypes of the serotonin transporter, of monoamine oxidases A and B, and of platelet monoamine oxidase B activity, which all have been shown to be of importance for behaviour and with obvious effects of interactions with environment. Under unfortunate circumstances constitutional properties might be strong enough to result in vulnerability for suicide, even with a modest influence of environment. |
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