DNA repair mechanisms in eukaryotes: Special focus in Entamoeba histolytica and related protozoan parasites |
| |
| Authors: | César López-Camarillo Mavil Lopez-Casamichana Christian Weber Nancy Guillen Esther Orozco Laurence A Marchat |
| |
| Institution: | 1. Universidad Autónoma de la Ciudad de México, Posgrado en Ciencias Genómicas, México D.F., Mexico;2. Institut Pasteur, Unité Biologie Cellulaire du Parasitisme, Paris, France;3. INSERM U786, Paris, France;4. CINVESTAV-IPN, Departamento de Infectómica y Patogénesis Molecular, México D.F., Mexico;5. Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía, Programa Institucional de Biomedicina Molecular, México D.F., Mexico;1. Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center, Beijing, PR China;2. Department of Pathology, Beijing Hospital, Beijing, PR China;3. Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, PR China;4. Department of Gynecology, Peking University Third Hospital, Beijing, PR China;1. Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116023, China;2. Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576, Singapore |
| |
| Abstract: | Eukaryotic cell viability highly relies on genome stability and DNA integrity maintenance. The cellular response to DNA damage mainly consists of six biological conserved pathways known as homologous recombination repair (HRR), non-homologous end-joining (NHEJ), base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and methyltransferase repair that operate in a concerted way to minimize genetic information loss due to a DNA lesion. Particularly, protozoan parasites survival depends on DNA repair mechanisms that constantly supervise chromosomes to correct damaged nucleotides generated by cytotoxic agents, host immune pressure or cellular processes. Here we reviewed the current knowledge about DNA repair mechanisms in the most relevant human protozoan pathogens. Additionally, we described the recent advances to understand DNA repair mechanisms in Entamoeba histolytica with special emphasis in the use of genomic approaches based on bioinformatic analysis of parasite genome sequence and microarrays technology. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
