Successful Treatment of Esophageal Cancer with Airway Invasion with Induction Chemotherapy and Concurrent Chemoradiotherapy |
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Authors: | Geoffrey Y Ku Karyn A Goodman Valerie W Rusch David H Ilson |
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Institution: | 2. Department of Radiation Oncology, New York City, New York;3. Thoracic Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, New York |
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Abstract: | Esophageal cancer with airway invasion with or without fistula presents a challenging therapeutic dilemma with no standard therapy. Recent studies in Japan have focused on the use of definitive chemoradiotherapy. However, this approach is associated with significant treatment-related morbidity and mortality. We present a case report of a patient with thoracic esophageal squamous cell carcinoma with bronchial invasion who was treated to a clinical complete response with induction chemotherapy followed by consolidation with concurrent chemoradiotherapy. The patient also underwent restaging with a positron emission tomography scan after induction chemotherapy. Such a staged approach may reduce the morbidity of upfront radiation. The use of an interim positron emission tomography scan may also identify early treatment failure. |
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Keywords: | Esophageal cancer Squamous cell carcinoma Combined modality therapy Induction chemotherapy Chemoradiotherapy |
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